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Structurally Diverse Manganese(II)–Diclofenac Complexes Showing Enhanced Antioxidant Activity and Affinity to Serum Albumins in Comparison to Sodium Diclofenac
Author(s) -
Zampakou Marianthi,
Tangoulis Vassilis,
Raptopoulou Catherine P.,
Psycharis Vassilis,
Papadopoulos Athanasios N.,
Psomas George
Publication year - 2015
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201500078
Subject(s) - chemistry , diclofenac sodium , diclofenac , denticity , bovine serum albumin , chelation , manganese , medicinal chemistry , sodium , antioxidant , nuclear chemistry , organic chemistry , metal , chromatography , biochemistry
The interactions of Mn II ions with the nonsteroidal anti‐inflammatory drug sodium diclofenac in the presence of 1,10‐phenanthroline and 2,2′‐dipyridylamine lead to the formation of the trinuclear [Mn 3 (diclofenac) 6 (1,10‐phenanthroline) 2 (MeOH)] ( 1 ) and the mononuclear [Mn(diclofenac) 2 (2,2′‐dipyridylamine)] ( 2 ), respectively, which have been characterized by X‐ray crystallography. Three different coordination modes of the diclofenac ligands exist in 1 , whereas the bidentate chelating mode is observed in 2 . In the initial evaluation of their biological properties and potential applications, the complexes exhibited good binding propensity to human or bovine serum albumin proteins and have relatively high binding constants. The ability of the compounds to scavenge 1,1‐diphenylpicrylhydrazyl, 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid), and hydroxyl radicals was evaluated, and 1 was the most‐effective scavenger among 1 , 2 , and sodium diclofenac.