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New Gold(I) Organometallic Compounds with Biological Activity in Cancer Cells (Eur. J. Inorg. Chem. 27/2014)
Author(s) -
Bertrand Benoît,
de Almeida Andreia,
van der Burgt Evelien P. M.,
Picquet Michel,
Citta Anna,
Folda Alessandra,
Rigobello Maria Pia,
Le Gendre Pierre,
Bodio Ewen,
Casini Angela
Publication year - 2014
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201490137
Subject(s) - thioredoxin reductase , chemistry , moiety , stereochemistry , coumarin , gold compounds , cancer cell , ligand (biochemistry) , combinatorial chemistry , thio , thioredoxin , cancer , biochemistry , enzyme , organic chemistry , receptor , medicine
The cover picture shows the uptake of organometallic gold(I) N‐heterocyclic (NHC) complexes, bearing a fluorescent coumarin moiety, in cancer cells and the resulting anticancer effects. Notably, the most effective compound of the reported series bears the 1‐thio‐β D ‐glucose tetraacetate ligand, which may enhance its cellular uptake, therefore making the compound more cytotoxic. Once inside the cells, the gold compound may target the selenoenzyme thioredoxin reductase and induce mitochondrial damage. Details are discussed in the Short Communication by E. Bodio, A. Casini et al. on p. 4532 ff . For more on the story behind the cover research, see the Cover Profile .