Premium
Metallo‐β‐lactamases and Their Biomimetic Complexes (Eur. J. Inorg. Chem. 18/2014)
Author(s) -
Daumann Lena J.,
Schenk Gerhard,
Gahan Lawrence R.
Publication year - 2014
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201490086
Subject(s) - chemistry , ampicillin , cover (algebra) , antibiotics , penicillin , bacteria , hydrolysis , combinatorial chemistry , microbiology and biotechnology , biochemistry , mechanical engineering , biology , engineering , genetics
The cover picture shows a Petri dish with E. coli bacteria colonies engineered to grow on media treated with ampicillin. The protein structures depict metallo‐β‐lactamase NDM‐1 bound to the inhibitor captopril and hydrolyzed ampizillin. The use and overuse of antibiotics such as penicillin (top right) is a major contributor to antibiotic resistance. Details are presented in the Microreview by L. R. Gahan et al. on p. 2869 ff . For more on the story behind the cover research, see the Cover Profile .