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Copper Complexes of N‐Donor Ligands as Artificial Nucleases (Eur. J. Inorg. Chem. 16/2014)
Author(s) -
Wende Christian,
Lüdtke Carsten,
Kulak Nora
Publication year - 2014
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201490076
Subject(s) - chemistry , dna , cleavage (geology) , copper , cover (algebra) , combinatorial chemistry , ligand (biochemistry) , stereochemistry , biochemistry , receptor , organic chemistry , mechanical engineering , geotechnical engineering , fracture (geology) , engineering
The cover picture shows metal complexes capable of cleaving DNA, so‐called artificial metallonucleases. The DNA‐cleaving agents presented in the Microreview by N. Kulak et al. on p. 2597 ff . are based on copper as the central atom and comprise N‐donor ligands. Heteroaromatic, macrocyclic, and peptidic ligand systems (adumbrated in the background) are covered in detail. Whereas the focus of the Microreview is on the coordination chemistry of these artificial nucleases and the mechanism of DNA cleavage, potential applications in medicine and molecular biology are also briefly discussed. For more on the story behind the cover research, see the Cover Profile .