Nitric Oxide and Nitroxyl Products from the Reaction of  L ‐Cysteine with  trans ‐[RuNO(NH 3 ) 4 P(OEt) 3 ](PF 6 ) 3 | Zendy

Pereira José Clayston Melo | Zendy; Souza Maykon Lima | Zendy; Franco Douglas Wagner | Zendy

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Nitric Oxide and Nitroxyl Products from the Reaction of L ‐Cysteine with trans ‐[RuNO(NH 3 ) 4 P(OEt) 3 ](PF 6 ) 3

Author(s) -

Pereira José Clayston Melo,

Souza Maykon Lima,

Franco Douglas Wagner

Publication year - 2015

Publication title -

european journal of inorganic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.667

H-Index - 136

eISSN - 1099-0682

pISSN - 1434-1948

DOI - 10.1002/ejic.201402992

Subject(s) - chemistry , medicinal chemistry , ruthenium , cysteine , yield (engineering) , nitroxyl , stereochemistry , inorganic chemistry , catalysis , organic chemistry , materials science , metallurgy , enzyme

The reaction between the trans ‐[RuNO(NH 3 ) 4 P(OEt) 3 ](PF 6 ) 3 and L ‐cysteine (RS – ) was studied over a pH range of 2.0–7.4. In this reaction, the concentrations of NO and HNO produced varied as a function of the pH of the solution. The first step of this reaction proceeded quickly [ k 1 = (3.5 ± 0.3) × 10 3 M –1 s –1 , pH = 3.5, 25 °C] and resulted in the formation of trans ‐[Ru(NH 3 ) 4 P(OEt) 3 N(O)SR] 2+ , which dissociated to yield trans ‐[Ru(NH 3 ) 4 P(OEt) 3 NO · ] 2+ and RS · . However, trans ‐[Ru(NH 3 ) 4 P(OEt) 3 N(O)SR] n –1 can react with a second L ‐cysteine, yielding trans ‐[Ru(NH 3 ) 4 P(OEt) 3 N(O)(SR) 2 ] + [ k 2 = (3.6 ± 0.1) M –1 s –1 , pH = 3.5, 25 °C]. Therefore, the trans ‐[Ru(NH 3 ) 4 P(OEt) 3 NO · ] 2+ species released NO and the trans ‐[Ru(NH 3 ) 4 P(OEt) 3 N(O)(SR) 2 ] n– 2 species released HNO.

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