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Nitric Oxide and Nitroxyl Products from the Reaction of L ‐Cysteine with trans ‐[RuNO(NH 3 ) 4 P(OEt) 3 ](PF 6 ) 3
Author(s) -
Pereira José Clayston Melo,
Souza Maykon Lima,
Franco Douglas Wagner
Publication year - 2015
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201402992
Subject(s) - chemistry , medicinal chemistry , ruthenium , cysteine , yield (engineering) , nitroxyl , stereochemistry , inorganic chemistry , catalysis , organic chemistry , materials science , metallurgy , enzyme
The reaction between the trans ‐[RuNO(NH 3 ) 4 P(OEt) 3 ](PF 6 ) 3 and L ‐cysteine (RS – ) was studied over a pH range of 2.0–7.4. In this reaction, the concentrations of NO and HNO produced varied as a function of the pH of the solution. The first step of this reaction proceeded quickly [ k 1 = (3.5 ± 0.3) × 10 3 M –1 s –1 , pH = 3.5, 25 °C] and resulted in the formation of trans ‐[Ru(NH 3 ) 4 P(OEt) 3 N(O)SR] 2+ , which dissociated to yield trans ‐[Ru(NH 3 ) 4 P(OEt) 3 NO · ] 2+ and RS · . However, trans ‐[Ru(NH 3 ) 4 P(OEt) 3 N(O)SR] n –1 can react with a second L ‐cysteine, yielding trans ‐[Ru(NH 3 ) 4 P(OEt) 3 N(O)(SR) 2 ] + [ k 2 = (3.6 ± 0.1) M –1 s –1 , pH = 3.5, 25 °C]. Therefore, the trans ‐[Ru(NH 3 ) 4 P(OEt) 3 NO · ] 2+ species released NO and the trans ‐[Ru(NH 3 ) 4 P(OEt) 3 N(O)(SR) 2 ] n– 2 species released HNO.