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Phosphate Diester Cleavage, DNA Interaction and Cytotoxic Activity of a Bimetallic Bis(1,4,7‐triazacyclononane) Zinc Complex
Author(s) -
Montagner Diego,
Gandin Valentina,
Marzano Cristina,
Erxleben Andrea
Publication year - 2014
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201402698
Subject(s) - chemistry , cleavage (geology) , bimetallic strip , zinc , in vitro , dna , phosphate , plasmid , stereochemistry , cytotoxic t cell , biochemistry , catalysis , organic chemistry , geotechnical engineering , fracture (geology) , engineering
Invited for the cover of this issue are researchers from the National University of Ireland, Galway, and the University of Padua, Italy. The cover image shows the X‐ray structure of the dinuclear bis(1,4,7‐triazacyclononane) zinc complex synthesized in this work. The complex converts supercoiled plasmid DNA into the nicked form at low micromolar concentration and shows promising in vitro antitumor activity against pancreatic and lung cancer cell lines.