Premium
Salicylate‐Functionalized Bismuth Oxido Clusters: Hydrolysis Processes and Microbiological Activity
Author(s) -
Schlesinger Maik,
Pathak Amita,
Richter Sebastian,
Sattler Dominik,
Seifert Andreas,
Rüffer Tobias,
Andrews Philip C.,
Schalley Christoph A.,
Lang Heinrich,
Mehring Michael
Publication year - 2014
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201402493
Subject(s) - chemistry , bismuth , electrospray ionization , fourier transform ion cyclotron resonance , hydrolysis , triclinic crystal system , mass spectrometry , nuclear chemistry , medicinal chemistry , inorganic chemistry , molecule , organic chemistry , chromatography
Hydrolysis of either Bi(HSal 4 Me) 3 ( A ) or [Bi 22 O 26 (HSal 4 Me) 14 ]( B ) in dmso gave the 4‐methylsalicylate‐substituted bismuth oxido cluster [Bi 38 O 45 (HSal 4 Me) 24 (dmso) 14 (H 2 O) 2 ] · 4H 2 O ( 1· 4H 2 O), which crystallizes in the triclinic space group P $\bar {1}$ with cell parameters of a = 20.7214(5), b = 20.9654(6), c = 22.2128(6) Å, α = 100.867(2), β = 114.108(2), γ = 107.895(2)° and V = 7815.1(4) Å 3 . The hydrolysis of A was studied by using 1 H DOSY NMR spectroscopy and electrospray ionization Fourier‐transform ion‐cyclotron‐resonance (ESI‐FTICR) mass spectrometry, both of which showed the formation of several larger species under ambient conditions in the presence of moisture. Furthermore, ESI‐FTICR MS analysis of cluster B showed the formation of mainly {Bi 23 O 26 } species, which indicates the partial dissociation of cluster B in solution. In addition, the three different bismuth species containing 1 ( A ), 22 ( B ) or 38 ( 1· 4H 2 O) bismuth atoms per molecular formula were tested for their microbiological activity against three strains of Helicobacter pylori (251, 26695 and B128). A minimum inhibitory concentration (MIC) of 6.25 μg mL –1 for the mononuclear bismuth complex A was obtained, whereas the bismuth oxido cluster B showed a lower activity with MIC values in the range 25–50.0 μg mL –1 . The activity of 1· 4H 2 O is comparable to commercial remedies based on antimicrobial bismuth subsalicylate (BSS; 12.5 μg mL –1 ).