Vanadium Complexes as Prospective Therapeutics: Structural Characterization of a V IV  Lysozyme Adduct | Zendy

Santos Marino F. A. | Zendy; Correia Isabel | Zendy; Oliveira Ana R. | Zendy; Garribba Eugenio | Zendy; Pessoa João Costa | Zendy; SantosSilva Teresa | Zendy

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Vanadium Complexes as Prospective Therapeutics: Structural Characterization of a V IV Lysozyme Adduct

Author(s) -

Santos Marino F. A.,

Correia Isabel,

Oliveira Ana R.,

Garribba Eugenio,

Pessoa João Costa,

SantosSilva Teresa

Publication year - 2014

Publication title -

european journal of inorganic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.667

H-Index - 136

eISSN - 1099-0682

pISSN - 1434-1948

DOI - 10.1002/ejic.201402408

Subject(s) - chemistry , lysozyme , covalent bond , crystallography , vanadium , adduct , electron paramagnetic resonance , side chain , stereochemistry , inorganic chemistry , nuclear magnetic resonance , organic chemistry , biochemistry , physics , polymer

The biological activity of vanadium complexes, namely, as insulin enhancers, is well known. We report a combined X‐ray crystallography, electron paramagnetic resonance, and density functional theory study of the interaction of vanadium picolinate complexes with hen egg white lysozyme (HEWL). We show that the V IV O(pic) 2 complex covalently binds to the COO – group of the side chain of Asp52 of HEWL. The long V IV =O bond obtained in the X‐ray study is explained to be due to reduction of V IV to V III during exposure of the crystals to the intense X‐ray beam.

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