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Electronic Origin of Out‐of‐Plane Distortions in Porphyrins
Author(s) -
Austeria Muthu P.,
Pancharatna Pattath D.,
Balakrishnarajan Musiri M.
Publication year - 2014
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201402157
Subject(s) - aromaticity , chemistry , porphyrin , steric effects , annulene , crystallography , atomic orbital , molecular orbital , computational chemistry , chemical physics , photochemistry , molecule , stereochemistry , electron , organic chemistry , physics , quantum mechanics
Porphyrins are noninnocent ligands that facilitate redox processes in many biological reactions. Though the porphyrin dianion is planar and aromatic, in many instances, its skeleton exhibits a variety of out‐of‐plane (OOP) distortions, which are primarily attributed to steric factors. Nevertheless, these distortions are suspected to play a hidden role in their biochemical reactions, as the nature of the distortion is conserved for a specific functionality across species. The propensity of porphyrins to assist redox reactions remains mysterious, as oxidation and OOP distortions affect their aromaticity. Our quantum chemical modelling of the two‐electron oxidation of porphyrin reveals that there are definite electronic reasons behind OOP distortions. An extension of the frontier orbital model of Gouterman to include the occupied b 1g , b 2g and a 1g (σ) molecular orbitals (MOs) is necessary to explain the nature and origin of OOP distortions. The distortions are the effect of the mixing of these σ‐type MOs with the π‐type a 1u and a 2u highest occupied molecular orbitals (HOMOs). These are further facilitated by the flexibility of the internal [16]annulene skeleton of the porphyrin framework. In the absence of transition metal ions, oxidation usually entails pronounced bond alternation along this internal cross owing to a 1u /a 2u mixing, which leads to the loss of aromaticity. However, this is accompanied by OOP distortions that help to retain the local aromaticity of the pyrrolic rings. Transition metal porphyrins with their energetically accessible d orbitals prefer OOP distortions over bond alternation and effectively conserve aromaticity. For late transition metal ions, the d 8 electronic configuration, which is ideal for a square‐planar complex, itself shows a variety of OOP distortions that stabilize the corresponding oxidation state through the mixing of the b 1g MO with the a 2u MO. For octahedral complexes with d 6 configuration of the central metal ion, a two‐electron oxidation is effectively supported by OOP distortions that result from the mixing of the b 2g MO with the a 2u MO. The a 1u MO is usually less prone to mixing as it is concentrated far away from the central metal ion. Despite involving σ–π mixing, these OOP distortions conserve the aromaticity as shown by the computed chemical shifts of the optimized porphyrin systems. In addition to explaining the origin of the noninnocent nature of porphyrins, our results also provides a basis for the rational prediction and control of the OOP distortions to suite the desired biomimetic applications.