Premium
[(1,3‐Bis{2,6‐bis(diphenylmethyl)‐4‐methylphenyl}imidazole‐2‐ylidene)PdCl 2 (NEt 3 )]: “Throwing Away” a Different Ancillary Ligand to Enhance the Catalytic Activity at Room Temperature
Author(s) -
Guest Daniel,
Chen MingTsz,
Tizzard Graham J.,
Coles Simon J.,
Turner Michael Lewis,
Navarro Oscar
Publication year - 2014
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201400072
Subject(s) - chemistry , imidazole , catalysis , ligand (biochemistry) , amination , aryl , combinatorial chemistry , palladium , triethylamine , medicinal chemistry , inert gas , organic chemistry , alkyl , receptor , biochemistry
Abstract A considerable effort in ligand design for catalysis in recent years has led to remarkable achievements in cross‐coupling reactions. In this work, we show that a careful selection of the ancillary ligands that complete the catalyst/precatalyst can provide an extra level of performance. Low loadings of [(IPr*)PdCl 2 (TEA)] {IPr* = 1,3‐bis[2,6‐bis(diphenylmethyl)‐4‐methylphenyl]imidazole‐2‐ylidene, TEA = triethylamine} catalyze the Buchwald–Hartwig amination reactions of aryl chlorides at room temperature in excellent yields, without the need for an inert atmosphere to set up or perform the reactions.