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A Metal‐Mediated Base Pair with a [2+1] Coordination Environment
Author(s) -
Richters Tim,
Müller Jens
Publication year - 2014
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201301491
Subject(s) - chemistry , denticity , base pair , imidazole , metal , stereochemistry , crystallography , duplex (building) , coordination complex , dna , crystal structure , organic chemistry , biochemistry
A silver(I)‐mediated base pair based on azole‐derived ligands only was devised. The base pair comprises the monodentate imidazole nucleoside and a nucleoside carrying the new bidentate ligand 4‐[(1 H ‐1,2,4‐triazol‐1‐yl)methyl]‐1 H ‐1,2,3‐triazole. The silver(I) ion is hence coordinated in a trigonal planar [2+1] environment. A representative DNA duplex comprising the new base pair is stabilized by 6 °C upon binding one equivalent of silver(I). CD spectroscopy was used to confirm that the duplex adopts the canonical B‐type conformation. The base pair represents the first example of a metal‐mediated base pair with a [2+1] coordination environment.