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Rhenium Complexes with Red‐Light‐Induced Anticancer Activity
Author(s) -
Wähler Kathrin,
Ludewig Anja,
Szabo Patrick,
Harms Klaus,
Meggers Eric
Publication year - 2014
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201301474
Subject(s) - chemistry , rhenium , singlet oxygen , photodynamic therapy , cytotoxicity , kinase , biophysics , oxygen , biochemistry , in vitro , inorganic chemistry , organic chemistry , biology
Rhenium(I) pyridocarbazole complexes with photoinduced antiproliferative activity are reported. The substitutionally inert complexes induce cell death by singlet oxygen generation upon irradiation with red light ( λ ≥ 620 nm), whereas only weak background cytotoxicity is observed in the dark. Owing to their ability to inhibit protein kinases (nanomolar IC 50 values against Pim1 at 10 μ M ATP), this class of rhenium complexes point in the direction of dual function antiproliferative therapy with a single drug in which photodynamic therapy is combined with the inhibition of cancer‐related protein kinases.