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Synthesis, Crystal Structure, DNA Binding, Antibacterial, and Cytotoxic Activities of Two Chiral Copper(II) Complexes
Author(s) -
Fei BaoLi,
Li Wen,
Xu WuShuang,
Long JianYing,
Liu QingBo,
Sun WeiYin,
Anson Christopher E.,
Powell Annie K.
Publication year - 2013
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201300685
Subject(s) - chemistry , intercalation (chemistry) , copper , stereochemistry , dna , schiff base , crystallography , trigonal bipyramidal molecular geometry , derivative (finance) , crystal structure , cytotoxic t cell , ion , inorganic chemistry , organic chemistry , in vitro , biochemistry , financial economics , economics
Two chiral copper(II) complexes [Cu(L) 2 Cl]Cl ( 1 ) and [Cu(L) 2 Br]Br ( 2 ) {L = N ‐[(pyridin‐2‐ylmethylene)imino]dehydroabietylamine} have been synthesized and fully characterized. The coordination geometry of the Cu II ions in 1 and 2 can be described as an intermediate between square‐pyramidal and trigonal‐bipyramidal. DNA binding studies suggest that the complexes interact with salmon‐sperm DNA through intercalation, and 2 exhibits a higher binding affinity. The new complexes were screened for their antibacterial and cytotoxic ability. They have similar cytotoxic activity and they represent the first rosin‐derivative‐based simple Schiff base complexes with strong anticancer potential.