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Synthesis of Na 2 { trans ‐[PdCl 2 (mTPPMS‐κ P ) 2 ]}: Interaction with DNA and Reactivity with 8‐Thiotheophylline
Author(s) -
SerranoRuiz Manuel,
Romerosa Antonio,
GarcíaMaroto Federico
Publication year - 2013
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201300293
Subject(s) - chemistry , palladium , reactivity (psychology) , crystallography , crystal structure , stereochemistry , x ray crystallography , nuclear chemistry , infrared spectroscopy , medicinal chemistry , catalysis , diffraction , organic chemistry , medicine , alternative medicine , pathology , physics , optics
The new water‐soluble palladium(II) complexes Na 2 { trans ‐[PdCl 2 (mTPPMS‐κ P ) 2 ]} ( 1 ), (CN 4 H 7 )Na{ trans ‐[PdCl 2 (mTPPMS‐κ P ) 2 ]} ( 2 ) and the 2D polymer trans ‐{Pd‐μ‐[mTPPMS‐1κ P :2κ O ‐Na 1/2 (H 2 O)]‐μ‐[mTPPMS‐1κ P :2κ O′ ‐Na′ 1/2 (H 2 O)]‐μ‐[8TTH‐1κ S :2κ O 6 – Na 1/2 (H 2 O)]‐μ‐[8TTH‐1κ S :2κ O 6‐Na′ 1/2 (H 2 O)]} n ( 3 ) {mTPPMS = Ph 2 P[3‐OS(O) 2 C 6 H 4 ] – ; 8‐TTH = 8‐thiotheophyllinate} have been synthesized and characterised by NMR and IR spectroscopy as well as elemental analysis. The crystal structures of 2 and 3 were determined by X‐ray diffraction. The binding properties of the new hydrosoluble palladium complexes towards DNA were studied by the mobility shift assay, which showed that complex 1 is more active than cisplatin towards DNA.