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Electrochemical Study of the Eu III /Eu II Redox Properties of Complexes with Potential MRI Ligands
Author(s) -
Gál Miroslav,
Kielar Filip,
Sokolová Romana,
Ramešová Šárka,
Kolivoška Viliam
Publication year - 2013
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201300252
Subject(s) - chemistry , electrochemistry , redox , polarography , cyclic voltammetry , dielectric spectroscopy , dota , stability constants of complexes , voltammetry , inorganic chemistry , chelation , electrode , aqueous solution
Abstract Properties of the Eu III /Eu II redox couple, in the presence of one of a group of different ligands of ligands, were investigated using several electrochemical methods. Ligands used in this study included cyclodextrins, polyazamacrocycles and poly(aminocarboxylates). The poly(aminocarboxylate) containing ligands currently used as MRI contrast agents (DTPA, DOTA) as well as newly developed ligands [1,4‐DOTA(GAC 12 ) 2 , 1,7‐DOTA(GAC 12 ) 2 ] with potential use as MRI contrast agents were studied. Cyclic voltammetry, phase sensitive AC voltammetry, DC polarography and highly effective electrochemical impedance spectroscopy were utilised to elucidate the mechanism of the reduction/oxidation of the Eu ion in the presence of these compounds. Stability constants of the Eu III and/or Eu II complexes and heterogeneous rate constants of the charge transfer were determined. Theoretical calculations of molecular volumes and diffusion coefficients were performed as well.