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Cobalt and Zinc Compounds Bearing 1,10‐Phenanthroline‐5,6‐dione or 1,3,5‐Triaza‐7‐phosphaadamantane Derivatives – Synthesis, Characterization, Cytotoxicity, and Cell Selectivity Studies
Author(s) -
Silva Telma F. S.,
Smoleński Piotr,
Martins Luísa M. D. R. S.,
Guedes da Silva M. Fátima C.,
Fernandes Alexandra R.,
Luis Daniel,
Silva Ana,
Santos Susana,
Borralho Pedro M.,
Rodrigues Cecília M. P.,
Pombeiro Armando J. L.
Publication year - 2013
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201300197
Subject(s) - chemistry , cytotoxicity , zinc , phenanthroline , stereochemistry , cobalt , coordination complex , in vitro , medicinal chemistry , metal , crystallography , biochemistry , organic chemistry
The compounds [mPTA][CoCl 4 ] ( 1 , mPTA = N ‐methyl‐1,3,5‐triaza‐7‐phosphaadamantane cation), [CoCl(H 2 O)(DION) 2 ][BF 4 ] ( 2 , DION = 1,10‐phenanthroline‐5,6‐dione), [Zn(DION) 2 ]Cl 2 ( 3 ) and [ZnCl(κ O ‐PTA=O)(DION)][BF 4 ] ( 4 ) were synthesized by reaction of CoCl 2 with [mPTA]I or DION and ZnCl 2 with DION or 1,3,5‐triaza‐7‐phosphaadamantane‐7‐oxide (PTA=O) and DION, respectively. All complexes are water soluble and have been characterized by IR, far‐IR, 1 H, 13 C and 31 P{ 1 H} NMR spectroscopy, ESI‐MS, elemental analyses and single‐crystal X‐ray diffraction structural analysis (for 1 ). They were screened against the human tumour cell lines HCT116, HepG2 and MCF7. Complexes 2 and 3 exhibit the highest in vitro cytotoxicity and show lower cytotoxic activities in normal human fibroblast cell line than in HCT116 tumour cell line, which demonstrates their slight specificity for this type of tumour cell.