Premium
Manganese‐Enhanced MRI Contrast Agents: From Small Chelates to Nanosized Hybrids The Development of Iron(II) Complexes as ParaCEST MRI Contrast Agents Lanthanide Complexes as Paramagnetic Probes for 19 F Magnetic Resonance The Solution Structure and Dynamics of MRI Probes Based on Lanthanide(III) DOTA as Investigated by DFT and NMR Spectroscopy (Eur. J. Inorg. Chem. 11/2012)
Author(s) -
KuenyStotz Marie,
FelderFlesch Delphine,
Morrow Janet R.,
Parker David,
Kuprov Ilya,
PlatasIglesias Carlos
Publication year - 2012
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201290035
Subject(s) - chemistry , cyclen , lanthanide , gadolinium , manganese , paramagnetism , dota , ligand (biochemistry) , contrast (vision) , mri contrast agent , nuclear magnetic resonance , chelation , crystallography , stereochemistry , inorganic chemistry , computer science , physics , artificial intelligence , ion , organic chemistry , quantum mechanics , biochemistry , receptor
The cover picture highlights various aspects of research in the field of metal‐based MRI probes. The picture includes graphics from four Microreviews in this Cluster Issue superimposed on an angiographic MRI image. Shown at the bottom left is a macromolecular Mn II complex (D. Felder‐Flesch, M. Kueny‐Stotz, and A. Garofalo), which is an example of manganese‐enhanced MRI contrast agents. At the bottom right, the optimization of the CEST effect for a Fe II complex at close to physiological pH (J. R. Morrow and S. J. Dorazio) is depicted. Right next to it is a pseudocontact shift field around a model of a lanthanide–DOTA complex (D. Parker, I. Kuprov, and P. Harvey), illustrating the physicochemical basis of probe design for 19 F MRS and MRI applications. At the top left is an energy diagram for the enantiomerization process of a Ln III complex with a cyclen‐based ligand (C. Platas‐Iglesias), which reflects an improved understanding of the solution structure and dynamics of such systems. The molecular modeling representation of a typical MRI contrast agent, [Gd(DOTA)(H 2 O)] – , is shown next to it. We thank the authors for providing graphics for the cover and Dr. Giorgio Gatti for putting in his time and creativity to compose this insightful picture.