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Kinetic and Mechanistic Studies on the Reactions of the Reduced Vitamin B 12 Complex Cob(I)alamin with Nitrite and Nitrate (Eur. J. Inorg. Chem. 6/2012)
Author(s) -
Plymale Noah T.,
Dassanayake Rohan S.,
Hassanin Hanaa A.,
Brasch Nicola E.
Publication year - 2012
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201290011
Subject(s) - chemistry , nitrite , nitrate , nitric oxide , intracellular , vitamin c , enzyme , nitrosation , cover (algebra) , inorganic chemistry , biochemistry , computational chemistry , organic chemistry , mechanical engineering , engineering
The cover picture shows that nitrate and especially nitrite rapidly oxidize cob(I)alamin to cob(II)alamin. Enzyme‐bound cob(I)alamin is a short‐lived species whose formation is essential for the activity of both mammalian vitamin B 12 dependent enzymes. Nitrite and nitrate, intracellular levels of which are elevated during oxidative/nitrosative stress as a consequence of elevated nitric oxide levels, are generally considered to be benign species. Details are discussed in the article by N. E. Brasch et al. on p. 913 ff. The cover picture was designed by Rohan S. Dassanayake.