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D ‐Glucuronic Acid Coated Gd(IO 3 ) 3 ·2H 2 O Nanomaterial as a Potential T 1 MRI‐CT Dual Contrast Agent
Author(s) -
Lee Eun Jung,
Heo Woo Choul,
Park Jang Woo,
Chang Yongmin,
Bae JiEun,
Chae Kwon Seok,
Kim Tae Jeong,
Park Ji Ae,
Lee Gang Ho
Publication year - 2013
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201201481
Subject(s) - chemistry , nanomaterials , gadolinium , mri contrast agent , glucuronic acid , proton , absorption (acoustics) , iodine , nuclear magnetic resonance , nuclear chemistry , radiochemistry , nanotechnology , materials science , organic chemistry , physics , polysaccharide , quantum mechanics , composite material
To date, only a few nanosystems have been investigated as T 1 MRI‐CT dual contrast agents. The T 1 MRI‐CT dual functionality of a material depends on its longitudinal water‐proton relaxivity ( r 1 ) and X‐ray absorption strength. We explored Gd(IO 3 ) 3 · 2H 2 O nanomaterial because Gd is the most powerful element for T 1 MRI contrast agents, and both Gd and I absorb X‐ray radiation; Gd absorbs X‐ray radiation ca. 2.5 times more strongly than I. D ‐Glucuronic acid coated Gd(IO 3 ) 3 · 2H 2 O nanomaterial showed a very large r 1 of 52.3 s –1 m M –1 ( r 2 / r 1 = 1.21), which could be ascribed to hydrated water molecules in the lattice. Its X‐ray absorption intensity was also stronger than those of commercial molecular iodine CT contrast agents. This result clearly suggests that D ‐glucuronic acid coated Gd(IO 3 ) 3 · 2H 2 O nanomaterial is a potential T 1 MRI‐CT dual contrast agent.