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Synthesis of C 2 ‐Symmetric Dimeric Re I Peptide Complexes
Author(s) -
Herrick Richard S.,
Ziegler Christopher J.,
Kennedy Kathryn L.,
Luu Calvin,
Engle James T.
Publication year - 2013
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201201444
Subject(s) - chemistry , rhenium , glycylglycine , dimer , carboxylate , amide , amine gas treating , stereochemistry , center (category theory) , crystallography , peptide , medicinal chemistry , amino acid , organic chemistry , glycine , biochemistry
The reaction of [Re(CO) 3 (H 2 O) 3 ]Br or [Re(CO) 5 Cl] with two peptides, glycylglycine, or glycylalanine were investigated. Each reaction produced a unique, well‐defined product. Structural elucidation showed the formation of chiral compounds with the formula [Re(CO) 3 (Gly‐Xxx‐O)] 2 , Xxx = Gly ( 1 ), Ala ( 2 ). Each dimer displays C 2 symmetry and a nearly rectangular shape. The ligands are bound through the amine and amide carbonyl at a rhenium center and through the pendant carboxylate to the adjacent rhenium center. Both products are fully characterized by X‐ray structure elucidation.