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Asymmetric Transfer Hydrogenation of Ketones Catalyzed by Rhenium Complexes with Chiral Ferrocenylphosphane Ligands
Author(s) -
Mejía Esteban,
Aardoom Raphael,
Togni Antonio
Publication year - 2012
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201200693
Subject(s) - chemistry , rhenium , transfer hydrogenation , triethylamine , catalysis , medicinal chemistry , organic chemistry , combinatorial chemistry , ruthenium
We have prepared a series of new rhenium complexes containing chiral ferrocenyldiphosphane ligands of the Josiphos family, starting from commercially available rhenium sources. These new Re V oxido and nitrido complexes, several of which have been characterized by X‐ray crystallography, are air‐ and moisture‐stable and are active catalysts in the asymmetric transfer hydrogenation of ketones using 2‐propanol as the hydrogen source in the presence of substoichiometric amounts of triethylamine (TEA). The reaction proceeds cleanly with good to excellent yields (50–99 %) but with moderate enantioselectivity (up to 58 % ee ). A mechanism not involving hydridic species is proposed.