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“In situ” Activation of Racemic Ru II Complexes: Separation of trans and cis Species and Their Application in Asymmetric Reduction
Author(s) -
Facchetti Giorgio,
Cesarotti Edoardo,
Pellizzoni Michela,
Zerla Daniele,
Rimoldi Isabella
Publication year - 2012
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201200643
Subject(s) - chemistry , ruthenium , enantioselective synthesis , asymmetric hydrogenation , diamine , optically active , in situ , cis–trans isomerism , combinatorial chemistry , medicinal chemistry , catalysis , stereochemistry , organic chemistry
Ruthenium(II) dichlorides with racemic atropos‐biaryl‐based diphosphanes and optically active 1,2‐diphenylethane‐1,2‐diamine (DPEN) as ligands have been synthesised. trans and cis isomers were formed due to the low basicity of the diphosphane ligands, in particular, with BITIANP and BIMIP. The trans and cis species were easily separated by filtration. In particular, when rac ‐BITIANP was used in combination with chiral DPEN, the asymmetric separation of optically pure complexes in cis and trans arrangements was realised and they were used as precatalysts in the asymmetric hydrogenation of ketones. Matching and mismatching combinations exhibited different performances.