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Sequential Palladium‐Catalysed Direct Arylation Followed by Suzuki Coupling of Bromo‐2‐chloropyridines: Simple Access to a Variety of 2‐Arylpyridines
Author(s) -
Baloch Marya,
Roy David,
Bensaid Souhila,
Guerchais Véronique,
Doucet Henri
Publication year - 2012
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201200613
Subject(s) - chemistry , palladium , catalysis , suzuki reaction , combinatorial chemistry , base (topology) , coupling (piping) , organic chemistry , mechanical engineering , mathematical analysis , mathematics , engineering
2‐Arylpyridines are an important class of ligands for the synthesis of complexes with physical properties. We observed that the use of 3‐, 4‐ or 5‐bromo‐2‐chloropyridines allows the synthesis of a wide variety of heteroarylated 2‐arylpyridines by means of successive direct arylation and Suzuki coupling. For these two reactions, an air‐stable catalyst associated to a cheap and nontoxic base was employed as the catalyst. Moreover, a wide range of heteroarenes and functionalised arylboronic acids could be tolerated.