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Lipid‐Based Bio‐Nanohybrids for Functional Stabilisation of Influenza Vaccines
Author(s) -
Wicklein Bernd,
Martín del Burgo M. Ángeles,
Yuste María,
Darder Margarita,
Llavata Carmen Escrig,
Aranda Pilar,
Ortin Juan,
del Real Gustavo,
RuizHitzky Eduardo
Publication year - 2012
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201200579
Subject(s) - chemistry , adjuvant , lipid bilayer , sepiolite , aluminium hydroxide , colloid , bilayer , membrane , hydroxide , thermal stability , viral envelope , nanotechnology , chemical engineering , aluminium , biochemistry , glycoprotein , organic chemistry , immunology , materials science , raw material , biology , engineering
Lipid‐based bio‐nanohybrids were evaluated as carriers of viral particles in the development of thermally stable and efficacious vaccines against influenza A. Herein, the surfaces of the microfibrous clay sepiolite and the Mg/Al‐type layered double hydroxide were modified with a bilayer lipid membrane on which influenza A virions were immobilised. These vaccines were highly immunogenic in mice and stability studies revealed that thermal and lyophilisation resistance were significantly enhanced when compared with a standard aluminium adjuvant. These findings might be attributable to the colloidal behaviour in combination with the biomimetic interface which improves the carrier‐virus interactions and preserves the molecular architecture of the viral particles. All these characteristics make the here presented clay–lipid biohybrid materials promising candidates for vaccine formulations.