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Cyclodextrin Anchoring on Magnetic Fe 3 O 4 Nanoparticles Modified with Phosphonic Linkers
Author(s) -
Tudisco Cristina,
Oliveri Valentina,
Cantarella Maria,
Vecchio Graziella,
Condorelli Guglielmo G.
Publication year - 2012
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201200510
Subject(s) - chemistry , bifunctional , magnetic nanoparticles , covalent bond , nanoparticle , cyclodextrin , surface modification , fourier transform infrared spectroscopy , combinatorial chemistry , linker , grafting , x ray photoelectron spectroscopy , polymer chemistry , monolayer , organic chemistry , chemical engineering , polymer , catalysis , biochemistry , computer science , engineering , operating system
Magnetic Fe 3 O 4 nanoparticles (MNPs) have been covalently modified with β‐cyclodextrin (β‐CD) cavities by adopting a two‐step anchoring route based on particle prefunctionalization with a phosphonic monolayer, which acts as a covalent linker between the MNPs and β‐CD. Particular attention has been devoted to the study of the functionalization process by adopting bifunctional phosphonic linkers to investigate the efficiency of the anchoring group (phosphonic acid or ester) and the role of a second functional group. The grafting process of the phosphonic linkers has been monitored by using X‐ray photoelectron and FTIR spectroscopy. β‐CD has then been successfully anchored on MNPs prefunctionalized with (3‐aminopropyl)phosphonic acid. The ability of β‐CD‐functionalized nanoparticles to carry and slowly release some drugs has been tested by adopting the anti‐inflammatory drug diclofenac sodium salt as a model.