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Magnetoluminescent Agents for Dual MRI and Time‐Gated Fluorescence Imaging
Author(s) -
Smolensky Eric D.,
Zhou Yue,
Pierre Valérie C.
Publication year - 2012
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201200045
Subject(s) - terbium , chemistry , luminescence , nanoparticle , lanthanide , fluorescence , fluorescence lifetime imaging microscopy , polyethylene glycol , gadolinium , conjugated system , photochemistry , nanotechnology , organic chemistry , polymer , materials science , ion , physics , optoelectronics , quantum mechanics
The synthesis and properties of two luminescent iron oxide nanoparticles for dual imaging by MRI and time‐gated confocal microscopy are presented. These magnetoplasmonic agents consist of macrocyclic terbium complexes conjugated onto magnetite nanoparticles by a polyethylene glycol linker. Two macrocyclic terbium complexes were investigated: Tb‐DOTAm‐(Phen) 3 and Tb‐DOTAm‐(acetylene) 3 . Both complexes display the characteristic long luminescence lifetimes of lanthanides (0.8 ms and 1.3 ms, respectively), rendering them ideal for time‐gated luminescence spectroscopy and confocal imaging – a feature currently unexplored in multimodal imaging agents. Additionally, the 5 ± 1 nm magnetite nanoparticles, with their permeable PEG coating and stable dopamide anchor, render the two constructs efficient MRI contrast agents with longitudinal ( r 1 ) and transverse ( r 2 ) relaxivities of 9.8 m M –1 Fe s –1 and 98 m M –1 Fe s –1 at 60 MHz and 37 °C.