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Gd‐Aminoethyl‐DO3A Complexes: A Novel Class of pH‐Sensitive MRI Contrast Agents
Author(s) -
Giovenzana Giovanni B.,
Negri Roberto,
Rolla Gabriele A.,
Tei Lorenzo
Publication year - 2012
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201101296
Subject(s) - chemistry , moiety , amine gas treating , combinatorial chemistry , contrast (vision) , stereochemistry , organic chemistry , artificial intelligence , computer science
Molecular imaging relies on the availability of imaging probes designed to modify their efficiency in the presence of a specific parameter, among which pH is one of the most investigated. Introduction of an aminoethyl moiety into the well‐known DO3A platform imparts the desired pH sensitivity to the corresponding Gd 3+ complex. The amine group is accessible and easy to functionalize; in particular, the possibility of tuning its p K AH through N ‐substitution makes it a good pH‐responsive functionality to access a novel class of tailored pH‐sensitive MRI contrast agents. This was demonstrated by a relaxometric study on a functionalized Gd‐DO3A complex bearing a simple primary amine group and comparison with the results of the corresponding N , N ‐dimethyl analogue.