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Silica Nanoparticles for Bimodal MRI–Optical Imaging by Grafting Gd 3+ and Eu 3+ /Tb 3+ Complexes
Author(s) -
Pinho Sonia L. C.,
Faneca Henrique,
Geraldes Carlos F. G. C.,
Rocha João,
Carlos Luís D.,
Delville MarieHélène
Publication year - 2012
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201101110
Subject(s) - chemistry , gadolinium , lanthanide , nanoparticle , fluorescence , photoluminescence , relaxometry , grafting , magnetic nanoparticles , pyridine , magnetic resonance imaging , nuclear magnetic resonance , analytical chemistry (journal) , ion , nanotechnology , organic chemistry , materials science , polymer , radiology , medicine , physics , optoelectronics , spin echo , quantum mechanics
Bimodal magnetic resonance imaging (MRI)/optical probes for bioimaging were obtained by grafting two types of lanthanide metal ions, Gd 3+ and Eu 3+ /Tb 3+ , on the surface of SiO 2 nanoparticles. The resulting systems were endowed with relaxometry and photoluminescent properties, respectively. Grafting a pyridine‐based aromatic backbone on to the silica surface enhances the emission quantum yield of the Eu 3+ ‐containing nanoparticles fivefold compared to similar systems that bear no aromatic antennae. The emission properties of the mixed Ln 3+ /Gd 3+ ‐based nanoparticles are not influenced by the presence of Gd 3+ . The relaxometric properties of these samples are slightly better than the properties of commercial [Gd(DTPA)] 2 (DTPA = diethylenetriaminepentaacetate). When taken up by RAW 264.7 cells (mouse macrophage cell line), such bimodal probes exhibit both T 1 ‐weighted MRI increased contrast and fluorescence tracking.