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Thiolato‐Bridged Arene–Ruthenium Complexes: Synthesis, Molecular Structure, Reactivity, and Anticancer Activity of the Dinuclear Complexes [(arene) 2 Ru 2 (SR) 2 Cl 2 ]
Author(s) -
Ibao AnneFlore,
Gras Michaël,
Therrien Bruno,
SüssFink Georg,
Zava Olivier,
Dyson Paul J.
Publication year - 2012
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201101057
Subject(s) - chemistry , ruthenium , reactivity (psychology) , stereochemistry , group 2 organometallic chemistry , molecule , medicinal chemistry , organic chemistry , catalysis , medicine , alternative medicine , pathology
Treatment of an arene–ruthenium dichloride dimer with thiols RSH to lead to cationic trithiolato complexes of the type [(arene) 2 Ru 2 (SR) 3 ] + was shown to proceed through the neutral thiolato complexes [(arene) 2 Ru 2 (SR) 2 Cl 2 ], which have been isolated and characterized for arene = p ‐MeC 6 H 4 i Pr and R = CH 2 Ph ( 1 ), CH 2 CH 2 Ph ( 2 ), CH 2 C 6 H 4 ‐ p ‐ t Bu ( 3 ), and C 6 H 11 ( 4 ). The single‐crystal X‐ray structure analysis of the p ‐ tert ‐butylbenzyl derivative 3 reveals that the two ruthenium atoms are bridged by the two thiolato ligands without a metal–metal bond. The neutral dithiolato complexes[(arene) 2 Ru 2 (SR) 2 Cl 2 ] ( 1 – 3 ) are intermediates in the formation of the cationic trithiolato complexes [(arene) 2 Ru 2 (SR) 3 ] + ( 5 – 7 ). Of the new [(arene) 2 Ru 2 (SR) 2 Cl 2 ] complexes, derivative 2 is highly cytotoxic against human ovarian cancer cells, with IC 50 values of 0.20 μ M for the A2780 cell line and 0.31 for the cisplatin‐resistant cell line A2780cisR.