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Ligand Effect on Cobalt(II)‐Catalyzed Asymmetric Cyclopropanation with Diazosulfones – Approaching High Stereoselectivity through Modular Design of D 2 ‐Symmetric Chiral Porphyrins
Author(s) -
Zhu Shifa,
Cui Xin,
Zhang X. Peter
Publication year - 2012
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201101023
Subject(s) - cyclopropanation , chemistry , stereoselectivity , porphyrin , ligand (biochemistry) , reactivity (psychology) , cobalt , catalysis , chiral ligand , stereochemistry , combinatorial chemistry , enantioselective synthesis , organic chemistry , receptor , medicine , biochemistry , alternative medicine , pathology
A significant ligand effect study has been summarized for asymmetric cyclopropanation with diazosulfones catalyzed by Co II complexes of a series of D 2 ‐symmetric chiral porphyrins. The structure of the ligands was shown to play an important role in both the reactivity and the stereoselectivity of the reactions. Fine‐tuning of the porphyrin ligand environments led to the development of an efficient Co II ‐based catalytic system for cyclopropanation of styrene with diazosulfones in high diastereoselectivity and enantioselectivity.