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Lanthanide Complexes as Paramagnetic Probes for 19 F Magnetic Resonance
Author(s) -
Harvey Peter,
Kuprov Ilya,
Parker David
Publication year - 2012
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201100894
Subject(s) - chemistry , lanthanide , paramagnetism , nuclear magnetic resonance , nuclear magnetic resonance spectroscopy , relaxation (psychology) , spectroscopy , ion , magnetic resonance imaging , magnetic relaxation , resonance (particle physics) , analytical chemistry (journal) , crystallography , stereochemistry , atomic physics , magnetic field , organic chemistry , condensed matter physics , magnetization , medicine , social psychology , psychology , physics , quantum mechanics , radiology
The physicochemical basis of probe design for 19 F MRS and MRI applications is reviewed. Complexes that give a single major resonance in solution are described, in which the Ln 3+ ion is about 6 Å from the 19 F label. Sensitivity improvements of 15‐fold are reported in both imaging and spectroscopy based on longitudinal relaxation enhancement. The pseudocontact shift allows an amplification of chemical shift non‐equivalence in responsive 19 F probes, e.g. for monitoring pH in the range between 5 and 8.
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