A Highly Selective Fluorescent and Colorimetric Chemosensor for Zn II  and Its Application in Cell Imaging | Zendy

Xie Guoqiang | Zendy; Shi Yanjun | Zendy; Hou Fengping | Zendy; Liu Hongyan | Zendy; Huang Liang | Zendy; Xi Pinxian | Zendy; Chen Fengjuan | Zendy; Zeng Zhengzhi | Zendy

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A Highly Selective Fluorescent and Colorimetric Chemosensor for Zn II and Its Application in Cell Imaging

Author(s) -

Xie Guoqiang,

Shi Yanjun,

Hou Fengping,

Liu Hongyan,

Huang Liang,

Xi Pinxian,

Chen Fengjuan,

Zeng Zhengzhi

Publication year - 2012

Publication title -

european journal of inorganic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.667

H-Index - 136

eISSN - 1099-0682

pISSN - 1434-1948

DOI - 10.1002/ejic.201100804

Subject(s) - chemistry , fluorescence , biocompatible material , selectivity , metal ions in aqueous solution , fluorescence microscope , metal , intracellular , zinc , biosensor , live cell imaging , photochemistry , nuclear chemistry , combinatorial chemistry , nanotechnology , inorganic chemistry , cell , biochemistry , organic chemistry , medicine , physics , materials science , quantum mechanics , biomedical engineering , catalysis

A fluorescent, colorimetric chemosensor, L1 , based on 8‐aminoquinoline, has been developed as a sensor for Zn 2+ . L1 exhibited high selectivity and sensitivity towards Zn 2+ over other common metal ions in a physiological pH window with a 1:1 binding mode. The ability of L1 to monitor intracellular Zn 2+ in living cells has been examined by fluorescence microscopy and indicated that L1 is cell‐permeable and biocompatible. We hope that such Zn 2+ ‐selective sensors will find application in biomedical and environmental detection.

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