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A Highly Selective Fluorescent and Colorimetric Chemosensor for Zn II and Its Application in Cell Imaging
Author(s) -
Xie Guoqiang,
Shi Yanjun,
Hou Fengping,
Liu Hongyan,
Huang Liang,
Xi Pinxian,
Chen Fengjuan,
Zeng Zhengzhi
Publication year - 2012
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201100804
Subject(s) - chemistry , fluorescence , biocompatible material , selectivity , metal ions in aqueous solution , fluorescence microscope , metal , intracellular , zinc , biosensor , live cell imaging , photochemistry , nuclear chemistry , combinatorial chemistry , nanotechnology , inorganic chemistry , cell , biochemistry , organic chemistry , medicine , physics , materials science , quantum mechanics , biomedical engineering , catalysis
A fluorescent, colorimetric chemosensor, L1 , based on 8‐aminoquinoline, has been developed as a sensor for Zn 2+ . L1 exhibited high selectivity and sensitivity towards Zn 2+ over other common metal ions in a physiological pH window with a 1:1 binding mode. The ability of L1 to monitor intracellular Zn 2+ in living cells has been examined by fluorescence microscopy and indicated that L1 is cell‐permeable and biocompatible. We hope that such Zn 2+ ‐selective sensors will find application in biomedical and environmental detection.