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99m Tc I /Re I Tricarbonyl Complexes with Tridentate Cysteamine Based Ligands: Synthesis, Characterization and in vitro/in vivo Evaluation
Author(s) -
Moura Carolina,
Gano Lurdes,
Santos Isabel C.,
Santos Isabel,
Paulo António
Publication year - 2011
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201100796
Subject(s) - chemistry , cysteamine , chelation , in vivo , pharmacophore , in vitro , ligand (biochemistry) , biomolecule , mesoionic , stereochemistry , radiochemistry , nuclear chemistry , medicinal chemistry , biochemistry , inorganic chemistry , receptor , microbiology and biotechnology , biology
Tricarbonyl M I (M = Re, 99m Tc) complexes of a new tridentate cysteamine based chelator have been synthesized and fully characterized. To gain an insight into the usefulness of this new chelator for labeling biomolecules with a fac ‐[M(CO) 3 ] + core, the ligand framework has been functionalized with a N ‐(dialkylaminoalkyl) pharmacophore. The corresponding 99m Tc I complexes showed moderate affinity for melanin and moderate cell uptake by B16F1 murine melanoma cells, and therefore deserve further evaluation in vivo as radioactive probes for the detection of melanomas.