Premium
Electrostatic Interaction of Negatively Charged Core–Shell Nanoparticles with Antitumoral Cationic Platinum‐Based Complexes
Author(s) -
Gál Miroslav,
Híveš Ján,
Laus Michele,
Sparnacci Katia,
Ravera Mauro,
Gabano Elisabetta,
Osella Domenico
Publication year - 2011
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201100454
Subject(s) - chemistry , cationic polymerization , adduct , nanoparticle , platinum , ionic strength , electrostatic interaction , ionic bonding , surface charge , inorganic chemistry , ion , polymer chemistry , organic chemistry , chemical engineering , aqueous solution , catalysis , engineering , chemical physics
We report herein on the interaction between two cationic antiproliferative platinum compounds [namely cis ‐[PtCl(NH 3 ) 2 (py)]Cl ( 1 ) and trans , trans ‐[(NH 3 ) 2 Pt{NH 2 (CH 2 ) 4 NH 2 }PtCl(NH 3 ) 2 ](Cl) 2 ( 2 )] and novel poly(methyl methacrylate) core–shell nanoparticles (MS) bearing anionic SO 3 – arms, studied to determine whether such particles might serve as drug carriers for Pt drugs. Electrostatic forces hold together the resulting adducts such that in the presence of higher concentrations of other cations the Pt drug should be released quickly and easily. As expected from their electric charges, we found that the formation constant of the MS‐ 2 adduct is significantly higher than that of MS‐ 1 . Moreover, the stability of both adducts depends on the ionic strength and surface charge density of competing cations in the medium. The stability of the conjugates and the consequent retention and release of the drug from the nanoparticles will thus depend on both blood and extracellular fluid composition.