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Atom Transfer Radical Reactions as a Tool for Olefin Functionalization – On the Way to Practical Applications
Author(s) -
MuñozMolina José María,
Belderrain Tomás R.,
Pérez Pedro J.
Publication year - 2011
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201100379
Subject(s) - chemistry , intramolecular force , domino , olefin fiber , atom transfer radical polymerization , catalysis , tandem , atom (system on chip) , surface modification , combinatorial chemistry , organic synthesis , atom economy , transition metal , radical cyclization , photochemistry , organic chemistry , polymerization , materials science , composite material , computer science , embedded system , polymer
Transition‐metal‐catalyzed atom transfer radical reactions of halogenated compounds with olefins constitute a versatile tool in organic synthesis within the area of C–C bond forming transformations. The inter‐ or intramolecular versions, atom transfer radical addition (ATRA) or cyclization (ATRC), respectively, lead to the atom‐economic, useful synthesis of compounds that can be further functionalized. This contribution summarizes the recent developments in this area in terms of catalyst design as well as the applicability of this methodology in sequential, domino, or tandem reactions.