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Organometallic cis ‐Dichlorido Ruthenium(II) Ammine Complexes
Author(s) -
BetanzosLara Soledad,
Habtemariam Abraha,
Clarkson Guy J.,
Sadler Peter J.
Publication year - 2011
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201100250
Subject(s) - aquation , chemistry , ruthenium , adduct , bifunctional , dimer , stereochemistry , aqueous solution , medicinal chemistry , hydrolysis , diastereomer , catalysis , kinetics , organic chemistry , reaction rate constant , physics , quantum mechanics
Bifunctional neutral half‐sandwich Ru II complexes of the type [(η 6 ‐arene)Ru(NH 3 )Cl 2 ] where arene is p ‐cym ( 1 ) or bip ( 2 ) were synthesised by the reaction of N , N ‐dimethylbenzylamine (dmba), NH 4 PF 6 and the corresponding Ru II arene dimer, and were fully characterised. X‐ray crystallographic studies of [(η 6 ‐ p ‐cym)Ru(NH 3 )Cl 2 ] · {(dmba–H)(PF 6 )} ( 1a ) and [(η 6 ‐bip)Ru(NH 3 )Cl 2 ] ( 2 ) show extensive H‐bond interactions in the solid state, mainly involving the NH 3 and the Cl ligands, as well as weak aromatic stacking interactions. The half‐lives for the sequential hydrolysis of 1 and 2 determined by UV/Vis spectroscopy at 310 K ranged from a few minutes for the first aquation to ca. 45 min for the second aquation; the diaqua adducts were the predominant species at equilibrium. Arene loss during the aquation of complex 2 was observed. Upon hydrolysis, both complexes readily formed mono‐ and di‐9‐ethylguanine (9‐EtG) adducts in aqueous solution at 310 K. The reaction reached equilibrium after ca. 1.8 h in the case of complex 1 and was slower but more complete for complex 2 (before the onset of arene loss at ca. 2.7 h). Complexes 1 and 2 were not cytotoxic towards A2780 human ovarian cancer cells up to the maximum concentration tested (100 μM).