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Transition‐Metal Complexes Based on a Sulfonate‐Containing N‐Donor Ligand and Their Use as HIV Antiviral Agents
Author(s) -
GarcíaGallego Sandra,
Serramía M. Jesús,
Arnaiz Eduardo,
Díaz Laura,
MuñozFernández M. Angeles,
GómezSal Pilar,
Ottaviani M. Francesca,
Gómez Rafael,
de la Mata F. Javier
Publication year - 2011
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201001121
Subject(s) - chemistry , sulfonate , ligand (biochemistry) , human immunodeficiency virus (hiv) , transition metal , medicinal chemistry , metal , salt (chemistry) , stereochemistry , sodium , receptor , organic chemistry , virology , biochemistry , catalysis , biology
Herein, we describe the synthesis and characterization of a sulfonate‐containing N‐donor ligand in its sodium salt and acid forms, Na 2 [(DES)MeN(CH 2 ) 2 NMe(DES)] · 2H 2 O ( 1 ) and [(DES)MeN + H(CH 2 ) 2 N + HMe(DES)] · H 2 O ( 2 ), and its corresponding metal complexes, [{(DES)MeN(CH 2 ) 2 NMe(DES)}M(H 2 O) 2 ] · n H 2 O [M = Ni ( 3 ), Co ( 4 ), Cu ( 5 ) and Zn ( 6 )]. Treatment of HIV‐infected MT‐2 cells with Ni, Co and Cu complexes inhibit virus replication up to 50–70 % both in pre‐ and post‐infected cells as a result of dual preventive and therapeutic behaviour.