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A Dinuclear Gold(I)–Silver(I) Derivative of 2‐Cyclopentylidene‐2‐sulfanylacetic Acid and Related Complexes: Synthesis, Crystal Structures, Properties and Antitumor Activity
Author(s) -
Barreiro Elena,
Casas José S.,
Couce María D.,
Laguna Antonio,
LópezdeLuzuriaga José M.,
Monge Miguel,
Sánchez Agustin,
Sordo José,
Varela José M.,
López Ezequiel M. Vázquez
Publication year - 2011
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201000959
Subject(s) - chemistry , hela , mass spectrometry , single crystal , crystal structure , derivative (finance) , luminescence , crystallography , stereochemistry , medicinal chemistry , nuclear chemistry , in vitro , biochemistry , physics , optoelectronics , chromatography , economics , financial economics
The dinuclear complex [AgAu(PPh 3 ) 2 cpa] (H 2 cpa = 2‐cyclopentylidene‐2‐sulfanylacetic acid) was prepared by treating the precursor [Au(PPh 3 )(Hcpa)] with Ag(PPh 3 )NO 3 . The complex was characterised by spectroscopic methods (IR; 1 H, 13 C, 31 P NMR) and mass spectrometry, and the structure was solved by a single‐crystal X‐ray diffraction study. Luminescence and theoretical studies were carried out, and the antitumor activity was studied in vitro against HeLa‐229, A2780 and A2780cis cell lines. The related gold(I)–gold(I), [(AuPPh 3 ) 2 cpa], and silver(I)–silver(I), [(AgPPh 3 ) 2 cpa], compounds were also prepared and studied in the solid state and in solution.