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Silica–MOF Composites as a Stationary Phase in Liquid Chromatography
Author(s) -
Ameloot Rob,
Liekens Anuschka,
Alaerts Luc,
Maes Michael,
Galarneau Anne,
Coq Bernard,
Desmet Gert,
Sels Bert F.,
Denayer Joeri F. M.,
De Vos Dirk E.
Publication year - 2010
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201000494
Subject(s) - microporous material , materials science , dispersity , high performance liquid chromatography , adsorption , nucleation , composite number , phase (matter) , chemical engineering , particle size , metal organic framework , chromatography , particle (ecology) , silica gel , stationary phase , composite material , chemistry , organic chemistry , polymer chemistry , oceanography , engineering , geology
Metal‐organic framework materials (MOFs) are a class of microporous and crystalline materials with great potential for adsorption‐based separations. Harnessing the separation ability of these materials in high‐performance liquid chromatography (HPLC) requires the use of small and uniform particles in order to achieve good column packing. The well‐known MOF material [Cu 3 (BTC) 2 ] is, however, typically synthesized as a polydisperse mixture due to its nucleation and growth mechanism. It is demonstrated how a new synthesis method for [Cu 3 (BTC) 2 ] enables the formation of the MOF inside the pores of silica beads often used in chromatography, leading to monodisperse silica–MOF composite spheres with a uniform particle size of 3 μm. When employed as an HPLC stationary phase, this material combines the good column packing properties of the silica and separation ability of the MOF material.