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A Photo‐Caged Platinum(II) Complex That Increases Cytotoxicity upon Light Activation
Author(s) -
Ciesienski Katie L.,
Hyman Lynne M.,
Yang Daniel T.,
Haas Kathryn L.,
Dickens Marina G.,
Holbrook Robert J.,
Franz Katherine J.
Publication year - 2010
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201000098
Subject(s) - chemistry , platinum , ligand (biochemistry) , amide , cytotoxicity , stereochemistry , cisplatin , metal , photochemistry , combinatorial chemistry , catalysis , receptor , organic chemistry , biochemistry , in vitro , medicine , surgery , chemotherapy
A novel platinum(II) photocaged complex called [Pt(cage)] has been prepared and characterized by X‐ray crystallography. The complex contains a photolabile nitrophenyl group incorporated into the backbone of a tetradentate ligand that contains two pyridyl and two amide nitrogen donor sites. The intact complex is unreactive toward ligand‐exchange reactions until activation with UV light cleaves the ligand backbone, releasing a Pt II complex that more readily exchanges its ligands, as verified by reaction with a methionine‐containing peptide. [Pt(cage)] is non‐toxic to MCF‐7 cells in the dark, whereas brief UV exposure induces cell death of human breast cancer MCF‐7 cells at a level approaching that of cisplatin. By using light to alter the coordination chemistry around the metal center, [Pt(cage)] represents a new strategy for potentially delivering metal‐based drugs in a site and time specific manner.