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Synthesis, X‐ray Crystal Structures, DNA Binding and Nuclease Activities of Two Novel 1,2,4‐Triazole‐Based Cu II Complexes
Author(s) -
Li DongDong,
Tian JinLei,
Gu Wen,
Liu Xin,
Yan ShiPing
Publication year - 2009
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200900763
Subject(s) - chemistry , crystallography , octahedral molecular geometry , circular dichroism , square pyramidal molecular geometry , binding constant , copper , crystal structure , cyclic voltammetry , stereochemistry , binding site , electrochemistry , biochemistry , organic chemistry , electrode
Two novel 1,2,4‐triazole‐based copper(II) complexes have been synthesized and structurally characterized by X‐ray crystallography: [Cu 2 LCl 3 ] · 0.5[CuCl 4 ] · EtOH ( 1 ) and [Cu 2 LBr 3 ] · Br · H 2 O ( 2 ) (L = 3,5‐bis{[bis(2‐methoxyethyl)amino]methyl}‐4 H ‐1,2,4‐triazol‐4‐amine). Single‐crystal diffraction reveals that the two Cu atoms have a distorted octahedral geometry for 2 , but one Cu atom is in a distorted square‐pyramidal environment and the other one is in a distorted octahedral environment for 1 because of the different bridged halogen atoms. The interactions of the two complexes with calf thymus DNA (CT‐DNA) have been investigated by UV absorption, fluorescence spectroscopy, circular dichroism spectroscopy, viscosity measurements and cyclic voltammetry. The apparent binding constant ( K app ) values for complexes 1 and 2 are 2.98 × 10 6 and 4.05 × 10 6 M –1 . Furthermore, both the compounds display efficient oxidative cleavage of supercoiled DNA in the presence of external agents. The rate constants for the conversions of supercoiled to nicked DNA are 4.38 × 10 –4 s –1 (for 1 ) and 5.26 × 10 –4 s –1 (for 2 ). (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2010)