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In III and Ga III Complexes of Sugar‐Substituted Tripodal Trisalicylidene Imines: The First 68 Ga‐Labelled Sugar Derivative
Author(s) -
Gottschaldt Michael,
Bohlender Carmen,
Pospiech Anne,
Görls Helmar,
Walther Martin,
Müller Dirk,
Klette Ingo,
Baum Richard P.,
Schubert Ulrich S.
Publication year - 2009
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200900561
Subject(s) - chemistry , ligand (biochemistry) , octahedron , gallium , yield (engineering) , tris , nuclear magnetic resonance spectroscopy , mass spectrometry , crystallography , metal , inorganic chemistry , derivative (finance) , medicinal chemistry , stereochemistry , nuclear chemistry , crystal structure , organic chemistry , chromatography , receptor , biochemistry , materials science , economics , financial economics , metallurgy
Gallium and indium complexes derived from salicylaldimines of 1,1,1‐tris(aminomethyl)ethane (TAME) with pendantxylose, glucose and galactose units have been synthesised as model compounds for potential application as radiotracers. The formed neutral complexes have been characterised by NMR spectroscopy, elemental analysis, mass spectrometry and, in the case of the galactose‐bearing In III complex, by single‐crystal X‐ray structure analysis. Octahedral coordination was observed with the appearance of an equilibrium of Λ‐ and Δ‐isomers at the metal centre. The glucose‐appended ligand was radiolabelled with 68 Ga III ions in up to 98 % yield depending on the prevailing pH value. The in vitro stability of the radioactive complex was examined by challenge experiments against apo‐transferrin and blood plasma. Very high stability was observed; even after a period of 2 h, 90 % of the complex could still be detected. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)