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Cyclic Trinuclear Diorganotin(IV) Complexes – The First Tin Compounds Bearing Oximehydroxamate Ligands: Synthesis, Structural Characterization and High In Vitro Cytotoxicity
Author(s) -
Gajewska Malgorzata,
Luzyanin Konstantin V.,
Guedes da Silva M. Fátima C.,
Li Qingshan,
Cui Jingrong,
Pombeiro Armando J. L.
Publication year - 2009
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200900388
Subject(s) - chemistry , tin , solvent , intramolecular force , hydrogen bond , toluene , stereochemistry , nuclear magnetic resonance spectroscopy , medicinal chemistry , crystallography , molecule , organic chemistry
The reactions between equimolar amounts of R 2 SnO (R = Me 1 , n Bu 2 ) and N ,2‐dihydroxy‐5‐[ N ‐hydroxyethanimidoyl]benzamide (H 2 L) under solvent reflux conditions (in toluene for 1 and methanol for 2 ) for ca. 4 h led to the formation of the trinuclear tin complexes [R 2 Sn(L)] 3 (R = Me 3 , n Bu 4 ) isolated as colourless crystalline solids in ca. 85 % yield, which were characterized by IR, 1 H, 13 C and 119 Sn NMR spectroscopy, elemental analysis and (for 4 ) by X‐ray diffraction. The trinuclear Sn core is stabilized by multiple intramolecular hydrogen bonding interactions involving the hydroxamate ligands, whereas the uncoordinated oxime functions interact through intermolecular H‐bonds leading to cyclic hexameric assemblies. These complexes are stable in air, soluble in common solvents and moderately in water and represent the first examples of tin species containing ligatedoximehydroxamic acids. Complex 4 exhibits high in vitrotumour‐inhibiting activity against the following human cell lines: promyelocyticfina leukemia (HL‐60), hepatocellular carcinoma (Bel‐7402), gastric carcinoma (BGC‐823) andnasopharyngeal carcinoma (KB). (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)