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Equilibrium Studies on Complex‐Formation Reactions of Pd[(2‐(2‐aminoethyl)pyridine)(H 2 O) 2 ] 2+ with Ligands of Biological Significance and Displacement Reactions of DNA Constituents
Author(s) -
Shehata Mohamed R.,
Shoukry Mohamed M.,
AbdelShakour Fatma H.,
van Eldik Rudi
Publication year - 2009
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200900352
Subject(s) - chemistry , hydrolysis , pyridine , ionic strength , stability constants of complexes , equilibrium constant , ligand (biochemistry) , stoichiometry , medicinal chemistry , amino acid , kinetics , stereochemistry , reaction rate constant , inorganic chemistry , organic chemistry , ion , aqueous solution , biochemistry , physics , receptor , quantum mechanics
The [Pd(AEP)Cl 2 ] complex was synthesized and characterized, where AEP = 2‐(2‐aminoethyl)pyridine. The stoichiometry and stability constants of the complexes formed between various biologically relevant ligands (amino acids, peptides, DNA constituents and dicarboxylic acids) and [Pd(AEP)(H 2 O) 2 ] 2+ were investigated at 25 °C and 0.1 M ionic strength. The equilibrium constants for the substitution of representative coordinated ligands such as inosine, glycine or methionine by cysteine were calculated and the concentration distribution diagrams of the various species evaluated. The kinetics of base hydrolysis of free and coordinated amino acid esters was investigated. The effects of the medium dielectric constant and temperature on the kinetics of base hydrolysis of the glycine methyl ester in the presence of the [Pd(AEP)(H 2 O) 2 ] 2+ complex were studied and the activation parameters Δ H ≠ and Δ S ≠ for the hydrolysis process were determined.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)