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New Insights into the Chemistry of the Antineoplastic Lanthanum Complex Tris(1,10‐phenanthroline)tris(thiocyanato‐κ N )lanthanum(III) (KP772) and Its Interaction with Biomolecules
Author(s) -
Biba Florian,
Groessl Michael,
Egger Alexander,
Roller Alexander,
Hartinger Christian G.,
Keppler Bernhard K.
Publication year - 2009
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200900038
Subject(s) - chemistry , lanthanum , lanthanide , tris , biomolecule , phenanthroline , capillary electrophoresis , nuclear magnetic resonance spectroscopy , elemental analysis , mass spectrometry , coordination complex , nuclear chemistry , crystallography , inorganic chemistry , stereochemistry , metal , organic chemistry , chromatography , ion , biochemistry
The lanthanide complex tris(1,10‐phenanthroline)tris(thiocyanato‐κ N )lanthanum(III) [La(phen) 3 (NCS) 3 ] (KP772) is a promising anticancer drug candidate, capable of overcoming resistance of tumors to established chemotherapeutics. The compound was characterized by elemental analysis, IR, 1 H NMR spectroscopy, TG/DTA measurements, mass spectrometry and X‐ray diffraction analysis. The results indicate that KP772 is a neutral, nine‐coordinate complex. In addition the behavior in water, important for the application as a chemotherapeutic drug, and the binding to biomolecules was investigated by capillary electrophoresis and ICP‐MS.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)