New Insights into the Chemistry of the Antineoplastic Lanthanum Complex Tris(1,10‐phenanthroline)tris(thiocyanato‐κ N )lanthanum(III) (KP772) and Its Interaction with Biomolecules | Zendy

Biba Florian | Zendy; Groessl Michael | Zendy; Egger Alexander | Zendy; Roller Alexander | Zendy; Hartinger Christian G. | Zendy; Keppler Bernhard K. | Zendy

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New Insights into the Chemistry of the Antineoplastic Lanthanum Complex Tris(1,10‐phenanthroline)tris(thiocyanato‐κ N )lanthanum(III) (KP772) and Its Interaction with Biomolecules

Author(s) -

Biba Florian,

Groessl Michael,

Egger Alexander,

Roller Alexander,

Hartinger Christian G.,

Keppler Bernhard K.

Publication year - 2009

Publication title -

european journal of inorganic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.667

H-Index - 136

eISSN - 1099-0682

pISSN - 1434-1948

DOI - 10.1002/ejic.200900038

Subject(s) - chemistry , lanthanum , lanthanide , tris , biomolecule , phenanthroline , capillary electrophoresis , nuclear magnetic resonance spectroscopy , elemental analysis , mass spectrometry , coordination complex , nuclear chemistry , crystallography , inorganic chemistry , stereochemistry , metal , organic chemistry , chromatography , ion , biochemistry

The lanthanide complex tris(1,10‐phenanthroline)tris(thiocyanato‐κ N )lanthanum(III) [La(phen) 3 (NCS) 3 ] (KP772) is a promising anticancer drug candidate, capable of overcoming resistance of tumors to established chemotherapeutics. The compound was characterized by elemental analysis, IR, 1 H NMR spectroscopy, TG/DTA measurements, mass spectrometry and X‐ray diffraction analysis. The results indicate that KP772 is a neutral, nine‐coordinate complex. In addition the behavior in water, important for the application as a chemotherapeutic drug, and the binding to biomolecules was investigated by capillary electrophoresis and ICP‐MS.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

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