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Oxidovanadium Complexes for the Consumption of Alkylating Toxins (Eur. J. Inorg. Chem. 1/2009)
Author(s) -
Fautch Jessica M.,
Fanwick Phillip E.,
Wilker Jonathan J.
Publication year - 2009
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200890106
Subject(s) - chemistry , alkylation , reactivity (psychology) , ligand (biochemistry) , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , receptor , catalysis , medicine , alternative medicine , pathology
The cover picture shows oxidovanadium complexes transforming alkylating toxins into alcohols. Variation of the electron‐donating ability of the ligand was found to permit a degree of control over the reactivity with alkylating agents. Kinetic studies revealed a small range of k obsd. values for this series of K[VO 2 (salhyph(R) 2 )] complexes (R = –NO 2 , –H, –CH 3 , –OCH 3 ) examined. These experiments were carried out with an ultimate goal of developing compounds to consume toxins and prevent DNA alkylation damage. Details are discussed in the Short Communication by J. J. Wilker et al on p. 33 ff.