Premium
The Chemistry of Technetium–Water Complexes within the Manganese Triad: Challenges and Perspectives
Author(s) -
Alberto Roger
Publication year - 2009
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200800909
Subject(s) - chemistry , organometallic chemistry , triad (sociology) , coordination complex , biomolecule , group 2 organometallic chemistry , manganese , ligand (biochemistry) , metal ions in aqueous solution , metal , inorganic chemistry , molecule , organic chemistry , catalysis , psychology , biochemistry , receptor , psychoanalysis
The chemistry of technetium is essentially driven by radiopharmaceutical applications. These comprise the syntheses of novel complexes but, moreover, the combination of targeting biomolecules with metal complexes. Aqua ions are especially convenient for facilitatating the introduction of metal cations into biomolecules, but are nonexistent for Tc and Re in the Mn triad. This microreview will discuss the chemistry of those Tc complexes that contain H 2 O as ligands. Special attention will be payed to organometallic aqua ions, i.e. complexes that are typically organometallic with water as ligand. Of particular interest is the coordination chemistry of [M(OH 2 ) 3 (CO) 3 ] + (M = Mn, Tc, Re) complexes in water since it is the origin of the widely applied radiopharmaceutical research with 99m Tc and 188 Re. The chemistry of organometallic aqua ions is not confined to Werner‐type ligands, hence, a further emphasis will be placed on pure organometallic chemistry in water.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)