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Platinum(IV) Complexes of 3‐ and 4‐Picolinic Acids Containing Ammine or Isopropylamine Ligands – Synthesis, Characterization, X‐ray Structures, and Evaluation of Their Cytotoxic Activity against Cancer Cell Lines
Author(s) -
Macazaga María J.,
Rodríguez Jorge,
Quiroga Adoración G.,
Peregina Sandra,
Carnero Amancio,
NavarroRanninger Carmen,
Medina Rosa M.
Publication year - 2008
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200800591
Subject(s) - picolinic acid , isopropylamine , chemistry , platinum , stereochemistry , crystal structure , cancer cell lines , hydrogen bond , medicinal chemistry , molecule , crystallography , organic chemistry , cancer cell , cancer , catalysis , medicine
The preparation and characterization of the new complexes trans ‐[PtCl 4 (NH 3 )(3‐picolinic acid)] ( 1 ), trans ‐[PtCl 4 {NH 2 CH(CH 3 ) 2 }(3‐picolinic acid)] ( 2 ), trans ‐[PtCl 4 (NH 3 )(4‐picolinic acid)] ( 3 ), and trans ‐[PtCl 4 {NH 2 CH(CH 3 ) 2 }(4‐picolinic acid)] ( 4 ) are described. The main structural feature of these complexes is the presence of ligands capable of multiple hydrogen‐bonding interactions. Crystals of 1 , 2 , 3 , and 4 suitable for single‐crystal X‐ray diffraction were grown, and the molecular structures of these compounds are discussed. In contrast to the inactive parent Pt II complexes, the Pt IV complexes displayed cytotoxic activity against various cancer cell lines used at the National Cancer Institute (NCI) for in vitro screens. Once more, the isopropylamine derivatives showed the best cytotoxicity values. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)