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Palladium‐Catalysed Direct C‐H Activation/Arylation of Heteroaromatics: An Environmentally Attractive Access to Bi‐ or Polydentate Ligands
Author(s) -
Derridj Fazia,
Gottumukkala Aditya L.,
Djebbar Safia,
Doucet Henri
Publication year - 2008
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200800143
Subject(s) - chemistry , denticity , oxazole , palladium , nitrile , catalysis , combinatorial chemistry , medicinal chemistry , organic chemistry , crystal structure
Bi‐ or polydentate ligands based on heterocycles can be easily prepared by palladium‐catalysed C–H bond activation of heteroaromatics followed by heteroarylation with heteroaryl bromides. A variety of heteroaromatics such as furans, thiophenes, pyridines, thiazoles or oxazole derivatives have been employed and moderate to good yields were generally obtained using the air‐stable complex [PdCl(dppb)(C 3 H 5 )] as catalyst. A range of functions such as acetyl, formyl, ester or nitrile on the heteroaromatics is tolerated.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)