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Isolation of an Intermediate in the Platination of p ‐Nitroacetophenone 4‐Methylthiosemicarbazone: Potential Application as an Antitumor Drug
Author(s) -
Quiroga Adoración G.,
Cubo Leticia,
Miguel Pablo J. Sanz,
Moneo Victoria,
Carnero Amancio,
NavarroRanninger Carmen
Publication year - 2008
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200800003
Subject(s) - chemistry , reactivity (psychology) , crystal structure , ligand (biochemistry) , stereochemistry , medicinal chemistry , crystallography , biochemistry , receptor , medicine , alternative medicine , pathology
Abstract The investigation of the formation and reactivity of Pd and Pt thiosemicarbazone complexes has revealed an unstudied intermediate derived from p ‐nitroacetophenone 4‐methylthiosemicabazone (L1H 2 ). The L1H 2 ligand leads to a new complex [Pt(L1)(L1H 2 )] that supports the postulated mechanism of how cyclometallation reactions take place. All the newly synthesized complexes, [(Pd(L1) 4 ], [(Pt(L1) 4 ], and [Pt(L1)(L1H 2 )] ( 3 ), have been characterized and tested against MCF7, SF268, and NCI H460 cell lines. The crystal structure of [Pt(L1)(L1H 2 )] · dmso is reported. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)