Isolation of an Intermediate in the Platination of  p ‐Nitroacetophenone 4‐Methylthiosemicarbazone: Potential Application as an Antitumor Drug | Zendy

Quiroga Adoración G. | Zendy; Cubo Leticia | Zendy; Miguel Pablo J. Sanz | Zendy; Moneo Victoria | Zendy; Carnero Amancio | Zendy; NavarroRanninger Carmen | Zendy

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Isolation of an Intermediate in the Platination of p ‐Nitroacetophenone 4‐Methylthiosemicarbazone: Potential Application as an Antitumor Drug

Author(s) -

Quiroga Adoración G.,

Cubo Leticia,

Miguel Pablo J. Sanz,

Moneo Victoria,

Carnero Amancio,

NavarroRanninger Carmen

Publication year - 2008

Publication title -

european journal of inorganic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.667

H-Index - 136

eISSN - 1099-0682

pISSN - 1434-1948

DOI - 10.1002/ejic.200800003

Subject(s) - chemistry , reactivity (psychology) , crystal structure , ligand (biochemistry) , stereochemistry , medicinal chemistry , crystallography , biochemistry , receptor , medicine , alternative medicine , pathology

The investigation of the formation and reactivity of Pd and Pt thiosemicarbazone complexes has revealed an unstudied intermediate derived from p ‐nitroacetophenone 4‐methylthiosemicabazone (L1H 2 ). The L1H 2 ligand leads to a new complex [Pt(L1)(L1H 2 )] that supports the postulated mechanism of how cyclometallation reactions take place. All the newly synthesized complexes, [(Pd(L1) 4 ], [(Pt(L1) 4 ], and [Pt(L1)(L1H 2 )] ( 3 ), have been characterized and tested against MCF7, SF268, and NCI H460 cell lines. The crystal structure of [Pt(L1)(L1H 2 )] · dmso is reported. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

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